jwg 071 Search Results


jwg071  (MedChemExpress)
93
MedChemExpress jwg071
Jwg071, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jwg071/product/MedChemExpress
Average 93 stars, based on 1 article reviews
jwg071 - by Bioz Stars, 2026-03
93/100 stars
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jwg-071  (DiscoverX corporation)
90
DiscoverX corporation jwg-071
(A) Overlay of structures of XMD11–50 (green), JWG-048 (salmon), JWG-046 (orange), <t>JWG-071(pink),</t> JWG-069 (cyan) and XMD17–26 (yellow) highlighting the different curvature of the diazipinone ring system and deviation of the tail. (B) Overlay of Roco4/XMD11–50 (pdb code 4YZM, top), and ERK5/XMD17–26 (pdb code 4B99, bottom), crystal structure reveal differences in P-loop (red) conformation and explain observed R2 SAR. (C) Overlay of JWG-047 and XMD17–26 in complex with BRD4-BD1 reveal differences in local interactions and the presence of a new water molecule in the JWG-047. Composite-omit map of JWG-047 in 2Fo-Fc format with a σ-level at 2.0.
Jwg 071, supplied by DiscoverX corporation, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jwg-071/product/DiscoverX corporation
Average 90 stars, based on 1 article reviews
jwg-071 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier
jwg-071  (Merck & Co)
90
Merck & Co jwg-071
(A) Overlay of structures of XMD11–50 (green), JWG-048 (salmon), JWG-046 (orange), <t>JWG-071(pink),</t> JWG-069 (cyan) and XMD17–26 (yellow) highlighting the different curvature of the diazipinone ring system and deviation of the tail. (B) Overlay of Roco4/XMD11–50 (pdb code 4YZM, top), and ERK5/XMD17–26 (pdb code 4B99, bottom), crystal structure reveal differences in P-loop (red) conformation and explain observed R2 SAR. (C) Overlay of JWG-047 and XMD17–26 in complex with BRD4-BD1 reveal differences in local interactions and the presence of a new water molecule in the JWG-047. Composite-omit map of JWG-047 in 2Fo-Fc format with a σ-level at 2.0.
Jwg 071, supplied by Merck & Co, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jwg-071/product/Merck & Co
Average 90 stars, based on 1 article reviews
jwg-071 - by Bioz Stars, 2026-03
90/100 stars
  Buy from Supplier

Image Search Results


(A) Overlay of structures of XMD11–50 (green), JWG-048 (salmon), JWG-046 (orange), JWG-071(pink), JWG-069 (cyan) and XMD17–26 (yellow) highlighting the different curvature of the diazipinone ring system and deviation of the tail. (B) Overlay of Roco4/XMD11–50 (pdb code 4YZM, top), and ERK5/XMD17–26 (pdb code 4B99, bottom), crystal structure reveal differences in P-loop (red) conformation and explain observed R2 SAR. (C) Overlay of JWG-047 and XMD17–26 in complex with BRD4-BD1 reveal differences in local interactions and the presence of a new water molecule in the JWG-047. Composite-omit map of JWG-047 in 2Fo-Fc format with a σ-level at 2.0.

Journal: ACS chemical biology

Article Title: Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains

doi: 10.1021/acschembio.7b00638

Figure Lengend Snippet: (A) Overlay of structures of XMD11–50 (green), JWG-048 (salmon), JWG-046 (orange), JWG-071(pink), JWG-069 (cyan) and XMD17–26 (yellow) highlighting the different curvature of the diazipinone ring system and deviation of the tail. (B) Overlay of Roco4/XMD11–50 (pdb code 4YZM, top), and ERK5/XMD17–26 (pdb code 4B99, bottom), crystal structure reveal differences in P-loop (red) conformation and explain observed R2 SAR. (C) Overlay of JWG-047 and XMD17–26 in complex with BRD4-BD1 reveal differences in local interactions and the presence of a new water molecule in the JWG-047. Composite-omit map of JWG-047 in 2Fo-Fc format with a σ-level at 2.0.

Article Snippet: Having identified a kinase class-selective compound, the kinome wide selectivity of JWG-071 was assessed using the KinomeScan methodology (DiscoverX) across a panel of 468 human kinases at a concentration of 1 μM.

Techniques: